Inhibition of metalloproteinase activity during mitochondrial injury improves hemostatic function of platelets in arterial thrombosis. Washed platelets were treated for 60 minutes with CCCP (top row) or GM6001/CCCP (bottom row), labeled with calcein, and infused into anesthetized mice. Vascular injury was induced by superfusion with FeCl₃; thrombus growth was monitored until blood flow stopped. Images were selected to visualize the ability of treated platelets to adhere to the damaged vessel wall (tethering) and incorporate into the growing thrombus. GM6001/CCCP-treated platelets were incorporated into the growing thrombus to an extent similar to that seen with untreated platelets.²⁴