Schematic model of the regulation of inducible expression of the cellular antioxidative stress genes through Bach2 transcription factor. Bach2 possesses one nuclear localization signal (NLS) and one cytoplasmic localization signal (CLS). Bach2 is mainly localized in cytoplasm through its C-terminal evolutionarily conserved CLS. Oxidative stress induces the nuclear accumulation of Bach2 by inhibiting the CLS activity. Bach2 is a bZip protein that forms heterodimers with small Maf proteins. The heterodimers bind to MARE, which are most closely related to the antioxidant response elements (ARE) and repress transcription through ARE/MARE.