Lovastatin reduces cell viability in plasma cell lines, which is restored by GGOH. Plasma cell lines (A) RPMI 8226, (B) L363, (C) XG-1, and (D) U266 were treated for 4 days with solvent control or different concentrations of lovastatin (5, 10, 30, 50, or 100 μM) alone (▪) or in the presence of mevalonate (100 μM; ○), GGOH (10 μM; •), or 10 μM FOH (10 μM; □). The percentage of viable cells, relative to the solvent control-treated cells, was measured by using MTT assay. Experiments were performed 3 times in triplicate. Data are presented as mean ± SEM.