Figure 3.
Elevation in peripheral blood platelet counts in hCD34tTA × BCR/ABL mice. Controls (□) were a nontransgenic littermate and 2 single BCR/ABL transgenic mice. The numbers of platelets in the control animals did not change over time as shown and were comparable to the values obtained at a single time point in 8 additional control animals (1 nontransgenic littermate, 1 hCD34tTA single transgenic, and 6 BCR/ABL single transgenic mice). Expression of BCR/ABL in the double transgenic hCD34tTA ×BCR/ABL animals (▪; F280, C814, C815, and C819 in Table 1) caused a significant increase in the number of platelets in the peripheral blood of double transgenic animals, up to more than 5 × 106/mm.3
