Effect of TSP-1 on the proliferative ability of the matrix laid by the FGF-2-overproducing Tet-FGF2/HEC-1-B endometrial adenocarcinoma cells. Matrix laid by Tet-FGF2/HEC-1-B cells treated with tetracycline (low FGF-2; □) or not treated (high FGF-2; ▪) was prepared as described in “Materials and methods,” and exposed or not to 220 nM TSP-1. Endothelial cells were plated on the treated matrix. The number of proliferated cells was evaluated 72 hours later. Cell proliferation is expressed as fold increase in cell number compared with control matrix (low FGF-2). Results (mean ± SD) are from one experiment representative of 2 experiments.