Figure 3.
Effect of overexpression of Pgp or Bcl-xL on induction of apoptosis by imatinib. Parental or transduced K562 cells were cultured in the indicated concentrations of imatinib for 48 hours in the absence or presence of verapamil. The cells were assayed by flow cytometry for annexin V and 7AAD binding, which indicate apoptotic cells and dead cells, respectively. The average results ± SEM of triplicates for the total percentage of cells that were positive for expression of either annexin V or 7AAD or both are shown.
