Schematic representation of the uPA/uPAR-directed Stat1 signaling in coculture. The study proposes uPA/uPAR signaling at the cell surface results in the phosphorylation of Tyk2, Jak1, or both recruiting Stat1 to activate, dimerize, and translocate to the nucleus, leading to gene expression, inhibiting cell proliferation, and, through a different mechanism, to promote cell migration involving PI3K and small GTPases.