Effects on tumor growth of the treatments with L19mTNFα combined with melphalan. (A) F9 tumor growth curves after a single intravenous injection of PBS, 0.7 pmol/g L19mTNFα, TN11mTNFα, and rmTNFα, followed, after 24 hours, by melphalan 4.5 μg/g given intraperitoneally. The growth curve of animals treated with PBS only is also reported. F9 tumor volume is expressed in cm³ (mean ± SD). The treatments were performed at the times indicated by arrows. (B) WHEI-164 tumor growth curves after a single intravenous (IV) injection of PBS, 0.7 pmol/g L19mTNFα, and rmTNFα, followed, after 24 hours, by melphalan 4.5 μg/g given intraperitoneally (IP). The growth curve of animals treated with PBS only is also reported. WHEI-164 tumor volume is expressed in cm³ (mean ± SD). The treatments were performed at the times indicated by arrows.