Differential gene expression profiles in AA patients and healthy volunteers. Genes were grouped and displayed in the following categories: immune response, apoptosis-related, cell cycle and cell proliferation, stress response, cell growth and maintenance, and cell adhesion. Relative expression (normalized to the median) is displayed by color: genes at significantly higher levels are shown in red; those with significantly lower expression in green. Two biologic pools were tested. For pool-AA1 and pool-N1, sufficient RNA was available to create 3 technical replicates; for pool-AA2 and pool-N2, only a single chip could be tested. Immune response, apoptosis-related, and stress response genes were largely up-regulated while cell cycle and cell growth and maintenance genes were down-regulated in AA patients compared with controls.
