Expression profiles inATM-mutant,TP53-mutant, andATM/TP53wild-type B-CLLs. (A) Hierarchical clustering of ATM-mutant, TP53-mutant, and ATM/TP53 wild-type (wt) B-CLLs based on the expression of 64 genes in unirradiated tumors. (B) Hierarchical clustering of VH-unmutated and VH-mutated B-CLLs based on the expression of 144 genes in unirradiated tumors. (C) Hierarchical clustering of ATM-mutant, TP53-mutant, and ATM/TP53 wt B-CLLs based on the change in gene expression of 245 genes after IR. The horizontal axis of the color bar (below) represents normalized levels of gene expression on a continuous scale. Red indicates overexpression and green indicates underexpression relative to the mean. The vertical axis of the color bar indicates reliability of the data. Dark or unsaturated colors represent low trust, and bright, saturated colors represent high trust. Signal values per gene were normalized to the median value across all experiments.
