Transcripts discriminative betweenATM-mutant,TP53-mutant, andwtB-CLLs. (A) Twenty-six differentially expressed transcripts were identified after Bonferroni multiple testing discriminated among TP53/ATM wt, TP53-mutant, and ATM-mutant tumors. (B-C) Expression at the protein level, before and after irradiation, of a set of 6 selected genes (in panel B, PCNA, Bbc3, Apo1; in panel C, p21, Mdm2, NFκB) in ATM-mutant, TP53-mutant, and ATM/TP53 wt B-CLL tumors. Asterisks indicate independent ATM-mutant, TP53-mutant, and ATM/TP53 wt B-CLL tumors not used in microarray experiments. Actin expression was used as a loading control.