Phenotypic analysis of blood and tonsil CD8⁺T cells from control and AIM patients. Expression of (A) CD45RA and CCR7, (B) CD45RA and CD27, and (C) CD27 and CD28 was investigated on CD8⁺ T cells from paired samples of control and AIM blood and tonsil samples. Paired blood and tonsil samples from AIM patients were investigated for the expression of the same markers in total CD8⁺ T cells (middle panels) or tetramer-gated, antigen-specific CD8⁺ T cells (right panels). Representative results from 1 of at least 3 separate paired blood and tonsil specimens are shown. Percentages of gated cells in each quadrant are shown as an inset in each panel.