Growth arrest induced in NHL and MM cell lines with short telomeres. Multiple myeloma (A,B,F) and non-Hodgkin lymphoma (C,D,E,G) cell lines with different mean telomere lengths were plated in 6-well plates in the presence of PBS, GRN163 (1-10 μM), or a mismatch oligonucleotide control 227 (10 μM) for up to 40 days. Cells were harvested, counted, and replated in the presence of fresh drug or PBS every 3 to 5 days. Viable cells were enumerated 3 times by trypan blue dye exclusion using a hematocytometer and a phase-contrast microscope. Average cell numbers were obtained, and PDs were calculated using the formula P_n = P_n–1 + [([ln (total number of cells]) – (ln [number of cells plated])/ln²]. Data are shown as calculated PDs over days of treatment. Percentages of apoptotic or dead cells at the end of treatment were measured as the percentage of annexin/PI dual-staining cells by flow cytometry.