Protection of mice from lethal sepsis. Mice injected intraperitoneally with either AdhBPI or AdDl70.3 (5 × 10⁸ pfu) were challenged with a preparation containing both LPS (500 ng/mouse) and d-galactosamine (8 mg/kg). Mortality of mice (9 mice/group) was followed over a period of 2 days (A). In separate experiments, serum samples were taken from AdhBPI- or AdDl70.3-treated mice (4-5 mice/group) at 1.5 and 2.5 hours after LPS/d-galactosamine challenge and measured for TNF-α (B). Results are expressed as means ± SEM and are representative of 2 independent experiments. The difference in panel B between AdhBPI and AdDl70.3 is statistically significant at 2 time points (P ≤ .02).