Comparison of VWF proteolysis for homozygous Tyr/Tyr1584 and heterozygous Tyr/Cys1584 individuals. Proteolysis of VWF from 20 Tyr/Tyr homozygous individuals was measured in triplicate and the mean of each triplicate plotted (•). Similarly, the mean of triplicate proteolysis assays for heterozygous Tyr/Cys VWF was plotted (x). Major bars to the right of each data set indicate the mean; minor bars above and below indicate 1 SD each side of the mean. Proteolysis was expressed as the percent loss of VWF:CB (the loss of VWF:CB as a percentage of the T = 0 hours value).