Effect of a single administration of the small compounds on peripheral blood cell levels in normal CD rats. Male CD rats were injected subcutaneously with SSCL02446 nitrate (panel A), SSCL02447 nitrate (panel B), SSCL02448 nitrate (panel C), or rhG-CSF (panel D). Neutrophil (panels A-D), lymphocyte (panel E), monocyte (panel F), RBC (panel G), and platelet (panel H) counts were measured in peripheral blood. The arrows indicate the times of administration of small compounds and rhG-CSF. Blood samples were collected from the orbital sinus at 0, 5, 10, 24, and 48 hours after administration. Each point represents the mean of cell counts on 4 or 5 rats ± SEM. Differential cell counts were performed on at least 100 cells in each blood smear stained with Diff Quik. Significant differences (*P < .05; **P < .01) from vehicle were assessed by the Dunnett test.