Figure 2.
Dose-dependent accumulation of clofarabine in plasma. Blood samples were obtained and processed at the end of clofarabine infusion. Clofarabine concentrations in plasma were measured using HPLC/MS and were calculated as described. The number of patients studied at each dose level was 1 each at 11.5 and 15 mg/m2, 2 at 40 mg/m2, 7 at 52 mg/m2, and 2 at 70 mg/m2.
