Effect of tPA on blood pressure of rats. Blood pressure was determined in anesthetized rats 3 minutes after intravenous injection of saline (columns 1 and 4), 2 or 10 mg/kg tPA (columns 2 and 3, respectively), or 2 or 10 mg/kg TNK-tPA (columns 5 and 6, respectively). (Mean ± SD, *P < .0002 vs baseline.)