Figure 2.
Healthy subjects carrying the haplotype B or C display higher serum levels of OPN than homozygotes for haplotype A. Two groups of subjects were evaluated (ie, random healthy subjects [n = 50] and the healthy relatives belonging to the families shown in Figure 3 [n = 12]). The genotypes are indicated with different symbols as shown in the figure. The bold horizontal lines indicate the median values for each group; the dotted line, the 95th percentile of the controls. The P values were calculated using the Mann-Whitney U test.