Role of TF in LPS-induced lethality. (A) TAT complex levels were measured at 6 hours in mTF^+/–/hTF⁺ and low TF mice injected with either saline or LPS (10 mg/kg). Data are shown as mean ± SE (n = 5 per group). (B) Kaplan-Meier plot of the survival of mTF^+/–/hTF+ mice (solid line; n = 22) and low TF mice (dashed line; n = 21) after administration of LPS (10 mg/kg). (C-D) □ indicates TNF-α and IL-6 levels in mTF^+/–/hTF⁺ mice, and ▪ indicates levels in low TF mice (mean ± SE; n = at least 4 per group).