Role of PARs in LPS-induced lethality. (A) Survival of endotoxemic PAR-2^+/+ (solid line; n = 10) and PAR-2^–/– (dashed line; n = 9) mice. (B-C) LPS induction of TNF-α and IL-6 expression in PAR-2^+/+ (□) and PAR-2^–/– (▪). Data are shown as mean ± SE (3 to 6 mice per group). (D) Survival of endotoxemic PAR-1^+/+ (solid line; n = 11) and PAR-1^–/– (dashed line; n = 13). (E-F) LPS induction of TNF-α and IL-6 expression in PAR-1^+/+ (□) and PAR-1^–/– (▪). Data are shown as mean ± SE (3 to 6 mice per group). No statistically significant differences were observed.