Effects of ART on the different populations of HIV-1-specific cytokine-secreting CD4 T cells. (A) Changes in the percentage of HIV-1-specific total IFN-γ- and IL-2-secreting CD4 T cells at baseline (prior to ART) and after 12 months of treatment. (B) Mean ± SE of cumulative data on the proportion of HIV-1- and CMV-specific CD4 T cells within the different cytokine-secreting cell populations before and after ART.