Tracking the expression patterns of 12 000 mouse genes within the U74Av.2 gene chip. The images are generated using algorithms of the GeneSpring analysis program (described in “Materials and methods”). (A) The S mansoni–infected wild-type pattern (WT Infected) is set as default, with the high values (approaching 10) indicating genes that are highly expressed in bone marrow from these mice, with gradations approaching 0.1 indicating genes that are expressed minimally. The “overdrawn” lines indicate selected patterns (correlation coefficient ≥ 0.95); profile 1, at or near baseline (= 1.0) in all but IL-5–expressing, infected wild-type mice; profile 2, at baseline for all but the infected wild-type mice. Profiles 1 and 2 represent gene expression correlating directly with levels of serum IL-5 and bone marrow eosinophilia. Profile 3, is the inverse of profile 1, as shown. There were no transcripts corresponding to the inverse of profile 2. (B-D) Graphic representations of transcripts following expression patterns delineated by profiles 1, 2, and 3 respectively.