Lesions in LDLR^-/- mice transplanted with NF-κB1^-/- bone marrow have a more inflammatory phenotype. Representative lesions from wild-type (A) or NF-κB1^-/- (B) transplanted mice showing clear cellular differences. Toluidin staining; original magnification, × 200. (C) Lesion classification was categorized as 3 groups: foam cell lesions containing mainly large foam cells; inflammatory lesions containing large numbers of small cells resembling an inflammatory cellular infiltrate; and an intermediate group. Lesion type for wild-type (□) and NF-κB1^-/- (▧) transplanted mice is shown as a percentage of the total lesions. All 3 groups were analyzed by Fisher exact test, and a significant shift toward inflammatory lesions was observed in NF-κB1^-/- transplanted mice (P < .0001). (D) Cell adherence at the cap of the lesion was counted and indicated as the average number of cells per lesion. ^*P < .01. Error bars indicate SD.