Elevated angiogenesis-related gene expression and increased BM angiogenesis in MM. (A) Normalized expression values from gene chip Hu95av2 for angiogenesis-related IL-8 and angiopoetin-1 gene transcripts in CD138⁺ and CD138^– cells from BM from the patient with MM and the healthy twin. (B) Deparaffinized MM patient BM biopsy specimens from 2002 were immunostained with anti-CD34 Abs using a labeled streptavidin-biotin peroxidase; microvessels per high power field (× 100) and the grade of angiogenesis were evaluated.