Figure 1.
Figure 1. Percutaneous transfection of TFPI inhibits restenosis. Expression of exogenous TFPI detected by immunohistochemistry on days 2 (A-B) and 5 (C-D) after percutaneous transfection with Ad5TFPI–c-myc (1 × 109 pfu/mL) using either the anti-TFPI K2 mAb (A,C) or the anti–c-myc mAb (B,D). Scale bars indicate distance with × 20 (100 μm) and × 10 (200 μm) magnification. Intima (I) to media (M) ratio was determined on Elastica van Gieson–stained vascular sections derived from Ad5TFPI–c-myc– (E) and Ad5lacZ-transfected (F) rabbit femoral arteries by histomorphometric analysis. Internal elastic lamina (IEL) and external elastic lamina (EEL) indicated by arrows (→) delineate adventitia (A), media (M), and intima (I, ↔), which surround the vessel lumen (L). Size bar indicates 500μmat × 4 magnification. Results of I/M ratio (G) and residual lumen area (H) are shown as mean ± SD.

Percutaneous transfection of TFPI inhibits restenosis. Expression of exogenous TFPI detected by immunohistochemistry on days 2 (A-B) and 5 (C-D) after percutaneous transfection with Ad5TFPI–c-myc (1 × 109 pfu/mL) using either the anti-TFPI K2 mAb (A,C) or the anti–c-myc mAb (B,D). Scale bars indicate distance with × 20 (100 μm) and × 10 (200 μm) magnification. Intima (I) to media (M) ratio was determined on Elastica van Gieson–stained vascular sections derived from Ad5TFPI–c-myc– (E) and Ad5lacZ-transfected (F) rabbit femoral arteries by histomorphometric analysis. Internal elastic lamina (IEL) and external elastic lamina (EEL) indicated by arrows (→) delineate adventitia (A), media (M), and intima (I, ↔), which surround the vessel lumen (L). Size bar indicates 500μmat × 4 magnification. Results of I/M ratio (G) and residual lumen area (H) are shown as mean ± SD.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal