American Society of Hematology

Figure 3.

$Figure 3. TFPI mediates suppression of vascular gelatinolytic activity after balloon injury. Expression of rabbit MMP-2 (A-B) and rabbit MMP-9 (C-D) in control virus (Ad5lacZ)– and Ad5TFPI-transfected rabbit femoral arteries 21 days after PTA and gene delivery. The size bar indicates 500 μ at × 4 magnification. Percent fractional area is given as mean ± SEM (n = 24) in each group. Gelatinolytic activity of Ad5lacZ-transfected (E) and Ad5TFPI-transfected (F) vessel segments as shown by in situ zymography and quantitated using TissueQuest software. Stains used: Vector VIP Substrate for Peroxidase (A-D); and Texas Red and DAPI (E-F).$

TFPI mediates suppression of vascular gelatinolytic activity after balloon injury. Expression of rabbit MMP-2 (A-B) and rabbit MMP-9 (C-D) in control virus (Ad5lacZ)– and Ad5TFPI-transfected rabbit femoral arteries 21 days after PTA and gene delivery. The size bar indicates 500 μ at × 4 magnification. Percent fractional area is given as mean ± SEM (n = 24) in each group. Gelatinolytic activity of Ad5lacZ-transfected (E) and Ad5TFPI-transfected (F) vessel segments as shown by in situ zymography and quantitated using TissueQuest software. Stains used: Vector VIP Substrate for Peroxidase (A-D); and Texas Red and DAPI (E-F).

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