Effect of CMC-544 or CMA-676 on small Ramos BCL xenografts. (A) Effect of CMC-544 on the growth of small but established Ramos BCL xenografts is shown. The effect of an isotype-matched control conjugate, CMA-676, was also evaluated in the same tumor model (B). G5/44 dose is shown in antibody protein equivalents and CMC-544 dose is shown in CalichDMH equivalents. The dose of 7.5 mg/kg G5/44 is equivalent to the dose of antibody protein in 160 μg/kg of CMC-544. Results are presented as mean tumor mass ± SEM.