Pharmacokinetics of CMC-544 in nude mice. CMC-544 was administered intraperitoneally at 160 μg/kg to tumor-bearing (RL BCL) and nontumor-bearing nude mice. Serum was collected from these mice at different time intervals (n = 3 mice/time point) and assessed for the presence of CMC-544 as described in “Materials and methods.” CMC-544 is expressed as CalichDMH equivalents.