Figure 2.
Hyperactivation of naive peripheral B cells in HIV-1 infection. PBMCs were analyzed by 3-color flow cytometry for expression of CD19, CD27, CD70, and LAIR-1. Naive B cells were defined as the CD27– fraction of the gated CD19+ B cells. The expression of CD70 (A) and LAIR-1 (B) on naive (CD19+CD27–) B cells from HIV-1–infected and uninfected subjects are shown.