Figure 2.
Figure 2. Effect of JF959602 on mouse cAMP level. (A) Exposure of mouse platelets to JF959602 resulted in a dose-dependent increase in PGE1-induced cAMP levels (•) but not sodium nitroprusside–stimulated cGMP levels (○). Error bars represent mean ± 1 SD (n = 3). P < .01. (B) Infusion of 1.2 mg/kg JF959602 into mice elevated the basal cAMP levels in circulating platelets. Error bars represent mean ± 1 SD (n = 5), P < .0005.

Effect of JF959602 on mouse cAMP level. (A) Exposure of mouse platelets to JF959602 resulted in a dose-dependent increase in PGE1-induced cAMP levels (•) but not sodium nitroprusside–stimulated cGMP levels (○). Error bars represent mean ± 1 SD (n = 3). P < .01. (B) Infusion of 1.2 mg/kg JF959602 into mice elevated the basal cAMP levels in circulating platelets. Error bars represent mean ± 1 SD (n = 5), P < .0005.

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