C3aR antagonist SB 290157 accelerates G-CSF–induced mobilization in wt mice. Wt BALB/c mice were mobilized for 1, 3, or 6 days with G-CSF (250 μg/kg subcutaneously/day) (n = 24 animals/group). SB 290157 (500 μg/mouse) was injected intraperitoneally with the last dose of G-CSF. (A) The number of MNCs/μL PB. (B) The number of circulating CFU-GMs/100 μL PB. *P < .000 01 compared with mice mobilized for 3 days with G-CSF only.