The effect of SB 290157 on G-CSF–induced mobilization is dose-dependent. Wt BALB/c mice were mobilized for 3 days with G-CSF (250 μg/kg subcutaneously/day) (n = 12 animals/group). SB 290157 (0.01-1.0 μg/mouse) was injected intraperitoneally with the last dose of G-CSF. *P < .000 01 compared with mice mobilized for 3 days with G-CSF alone. Data are expressed as mean ± standard deviation.