Ferric chloride–induced thrombus formation in hyperfibrinogenemic mice. Thrombus growth was determined by measuring the time required to achieve a 75% reduction of preinjury flow rate. End-point time was not significantly shortened in hyperfibrinogenemic mice (Hifib and Hifib/TMPro) compared to wild-type (wt) or thrombomodulin-deficient mice (TMPro). Average time to 75% flow reduction indicated by horizontal bars.