Allergic inflammation and coagulation factors in BA model. BALF concentration of cytokines was measured by EIA. OVA-sensitized mice exposed to inhaled OVA (OVA group) were compared with nonsensitized mice exposed to saline (SAL). OVA group showed significant increase in BALF concentration of total protein (A), IL-4 (B), IL-13 (C), and IL-5 (D), but significant decrease in BALF level of IFN-γ (E) compared with the SAL group. The ratio of IL-5 to IFN-γ (F) and the BALF count of eosinophils (G) were significantly higher in OVA-sensitized mice than in the SAL group. The OVA group showed enhanced hyperresponsiveness to methacholine compared with the SAL group (H). The coagulation factors, thrombin (I) and soluble tissue factor (J), were significantly elevated in BALF from OVA mice compared with SAL mice. There was no significant difference in BALF concentrations of APC (K) between the 2 groups. The APC/thrombin ratio (L) was significantly decreased in the OVA group compared with the SAL group. Data represent the mean ± SD of measurements performed in 6 (SAL group) and 9 (OVA group) animals. *P < .05, compared with SAL group. **P < .001, compared to SAL group.