Effect of APC on IgE expression and APC dose dependency. (A) The BALF level of IgE was significantly decreased in the OVA + APC group compared with the OVA + SAL group. Data represent the mean ± SD of values obtained in 6 mice. (B) Enhanced secretion of IgE induced by IL-4 in primary murine lymphocytes was significantly suppressed by APC. The BALF levels of total protein and IgE were significantly decreased in OVA-sensitized mice (OVA + SAL group) treated with 300 μg/d inhaled APC (OVA + APC300 group) compared with those treated with inhaled normal saline (OVA + SAL group). Data represent the mean ± SD of 12 measurements from 2 separate experiments. *P < .05, compared with OVA + SAL. **P < .05, compared with SAL and IL-4 (–) group.