Growth parameters in 122 pediatric patients with SCD during 7 years of hydroxyurea therapy. (A) Change in weight (kg) and (B) change in height (cm) in our cohort of patients. Because some patients were already pubertal when hydroxyurea therapy was initiated, values for weight and height ranged widely. However, there was no evidence of adverse effects on growth rates; rather, steady increases were observed during the 7 years of therapy. Error bars represent standard deviation.