Polymorphisms of the γ-glutamylcarboxylase gene (CAA repeats in intron 6) and in vivo pharmacodynamic and pharmacokinetic outcomes of warfarin. (A) Time course of changes in warfarin daily dose and INR values during the observation period (7 months) in patients with various patterns of the microsatellite (CAA repeat) in the GGC gene. (B) Comparisons of warfarin clearance and INR/Cp among the 3 GGC genotypic groups. Bars represent the mean ± SD.