Change in the intracellular IFN-γ and IL-4 in CD4 peripheral blood lymphocytes from WT, CD8-depleted, NK-depleted, and CD8/NK-depleted mice. Fold increase was calculated by the following formula: percentage of cytokine-positive cells from transfused mouse/percentage of cytokine-positive cells from nontransfused mouse. The data are expressed as the mean (± SD) of the fold increases for 10 mice per group. • indicates WT; □, CD8-depleted; ▦, NK-depleted; ▧, CD8/NK-depleted. Significance values between WT and CD8-depleted mice are indicated (^*P < .001; ^**P = .02).