Persistence of porcine chimerism and enhanced human T-cell development in NOD/SCID-Tg mice grafted with human Thy/Liv tissues under the subcapsular space of both kidneys. Shown are porcine and human chimerisms in various tissues at 25 weeks after human Thy/Liv implantation. (A) Porcine hematopoietic chimerism in the WBCs, spleen (Spl), liver (Liv), and BM of NOD/SCID-Tg mice that received porcine BM transplants alone (○) or porcine BM transplants plus human Thy/Liv grafts (•). Each symbol represents an individual animal. (B) FCM profiles showing coengraftment of porcine and human cells in various tissues of a NOD/SCID-Tg mouse recipient of porcine BM transplants plus human Thy/Liv grafts. Numbers indicate the percentages of the corresponding cell populations. (C) Percentages of human CD45⁺, CD3⁺, CD4⁺, and CD8⁺ cells in various tissues of NOD/SCID-Tg mice that received porcine BM transplants plus human Thy/Liv (▪) or human Thy/Liv alone (□). Each symbol represents an individual animal.