Lin-bi HSCs generate skewed lineage contribution in the hematopoietic organs. Shown are representative data of the percentage of donor-type T lymphocytes (▦), B lymphocytes (□), and myeloid cells (▪) in blood, BM, and spleen. Unmanipulated control mice (A). Host repopulated by individual balanced (B), My-bi (C), and Ly-bi (D) HSC clones. Data are from primary hosts 6 to 8 months after transplantation. Numbers at the right of each bar indicate the percentage of total donor-type cells in the corresponding organs.