Figure 4.
![Figure 4. Hoxb4-/- BM cells have increased tolerance to 5-FU treatment. (A) In vivo repopulation of Hoxb4-/--derived and Hoxb4+/+-derived donor cells after double treatment with 5-FU (day 1 [d1] and day 5 [d5]). The 5-FU–treated cells were competed against fresh B6.SJL cells in lethally irradiated B6.SJL recipients. (B) Level of reconstitution was measured as peripheral blood cells at 17 weeks after transplantation (mean ± SD) (each bar = 16 recipient mice from 4 donors).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/103/11/10.1182_blood-2003-10-3557/6/zh80110461880004.jpeg?Expires=1736048259&Signature=HQ6MHNDg07JDKWqBix3v7WFRMetw0aaJNdrme8OuRAPYKSX3Jz7~GpJfJAeK4Aig2BTcuIvMjNaNTT4qpRerLgQxj21ZXGb84B8nd-GHyqYkB7c04ROKtKd40ZnNKfZhbV5aP26So-QqIkJiQ7MYZJ0WidKUmO874KDLH83wbmsgLhjLpYYl9MW8EA5zaAGXW16H8wE6GIykp3dLWv2iS~X9mL5SQ1Y1PRSv2pp5xA3xro5ZcLy3WqR1Bp3jfIqYueNksDz5X6yuRWHz3Q7cwAjjtnJjkY0cMSewANjJdD4vl2oMfXPUYXcgYvP6TjwGuXrlqDp9FIa7wPd4bGkcQA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Hoxb4-/-BM cells have increased tolerance to 5-FU treatment. (A) In vivo repopulation of Hoxb4-/--derived and Hoxb4+/+-derived donor cells after double treatment with 5-FU (day 1 [d1] and day 5 [d5]). The 5-FU–treated cells were competed against fresh B6.SJL cells in lethally irradiated B6.SJL recipients. (B) Level of reconstitution was measured as peripheral blood cells at 17 weeks after transplantation (mean ± SD) (each bar = 16 recipient mice from 4 donors).
