mCP-CML expression of TNFR1/TNFR2 or Fas is not required for CD8-mediated GVL. B6 recipients were irradiated and reconstituted with Mp210/NGFR-infected wild-type, TNFR1/TNFR2^-/-, or Faslpr progenitors, T-cell-depleted C3H.SW BM, with or without 106 C3H.SW CD8⁺ T cells. (A) Survival. P < .0001 for each CD4 recipient group versus BM alone. (B) Serial analysis of peripheral blood. Each row is an individual mouse. Staining with anti-NGFR is shown in red, and isotype for NGFR is shown in blue. Each row is a single mouse. Note the similarity among wild-type, Fas^lpr, and TNFR^-/- mCP-CML.