Figure 1.
The 5′ end of the humanKCC1gene. (A) Genomic organization of the 5′ end of the human KCC1 gene. One clone containing the KCC1 gene was isolated from a human genomic DNA library. This clone spanned a distance of approximately 90 kb and contained exons 1 to 3 of the KCC1 cDNA in an approximately 13.5-kb XbaI fragment. A partial restriction map of this 13.5-kb fragment with BamHI (b) and XbaI (X) is shown. (B) Structure of the 5′ end of the human KCC1 cDNA. A diagram of the 5′ end of the human KCC1 cDNA is shown. The location of the initiation codon is shown, as is the location of intron/exon boundaries. Box denotes sequences obtained by 5′ RACE. Arrows denote oligonucleotide primers used in 5′ RACE. 5′ ends of the published cDNA and the 5′-most EST (IMAGE 5174748) are shown.