Pten^+/-SHIP^-/- mice demonstrate increased hepatosplenomegaly and evidence of extramedullary hematopoiesis. (A) Organ weights expressed as percentages of body weight ± SEM. ^**P < .001 compared with wild-type and Pten^+/-, but not significantly different between Pten^+/-SHIP^-/- and SHIP^-/-. ^***P ≤ .005 compared with all genotypes. (B) Hematoxylin-and-eosin-stained sections of liver reveal multiple foci of extramedullary hematopoiesis in Pten^+/-SHIP^-/- mice. (C) Sections from age-matched SHIP^-/- controls revealing normal liver histology. Original magnification, × 40.