Peak TRF length according to GC experience. (A) Peak TRF length in GC-experienced and GC-inexperienced tumors, classified according to the presence or absence of somatic hypermutation. (B) GC-experienced tumors are divided into GC derived and post-GC-derived according to the presence or absence of ongoing somatic hypermutation. (C) How TRF length correlates with GC experience in CLL patients. Box plots indicate 25th percentile, median value, and 75th percentile (horizontal lines of rectangle from the bottom, respectively) and 10th and 90th percentiles (horizontal lines outside rectangle).