Figure 6.
![Figure 6. DNA DSB assay. (A) Representative neutral elution profile for K562 cells treated with 0 (▪), 5 (▾), 10 (•), or 20 (♦) μM etoposide in the absence (black symbols) or presence (white symbols) of 10 μM NU7026 for 1 hour prior to neutral elution. (B) Mean relative elution values (calculated at 50% [3H] retention). □ indicates etoposide alone; and ▪, etoposide + NU7026. Results are means from 4 independent experiments ± SD. P values were calculated using the 2-tailed unpaired Student t test in order to determine whether DSB levels were significantly different in the presence of NU7026 (P = .01, 5.0 μM; P = .183, 10 μM; P = .06, 20 μM).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/103/12/10.1182_blood-2003-07-2527/5/zh80120462640006.jpeg?Expires=1742859162&Signature=myfs~MNIg1YfC2SxtRdwiw6-90HvB9WJsQzMgc-R6cjGbPSaywnExEnBecw7v7-Xi4ErVFA2MxLMAy96bWyg3lB2qmR25YSFBQVQGBgOVTCOiFK21267tREL8LikB4fggPZ5g9BxJgawyc16FhuPAvJiG315EhOSYukZL9uGh5UM~PcXiyxAU8Y3VTYiyzG~WmyFny~Bb2FeAAyFdiz~obNIAAkLTPSNIidwY~h0ZxYGLRy-BucZQQu7telce7rovosR9J6CmgW2s6sT5cQXq33~WgO7T046w~F06RGf-Q8BR5b0Ab8FYP6yXH6Mk1J~60bCn~-mYVwk8TRTmLChlg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
DNA DSB assay. (A) Representative neutral elution profile for K562 cells treated with 0 (▪), 5 (▾), 10 (•), or 20 (♦) μM etoposide in the absence (black symbols) or presence (white symbols) of 10 μM NU7026 for 1 hour prior to neutral elution. (B) Mean relative elution values (calculated at 50% [3H] retention). □ indicates etoposide alone; and ▪, etoposide + NU7026. Results are means from 4 independent experiments ± SD. P values were calculated using the 2-tailed unpaired Student t test in order to determine whether DSB levels were significantly different in the presence of NU7026 (P = .01, 5.0 μM; P = .183, 10 μM; P = .06, 20 μM).
