Hoxa7^-/- cells transformed by MLL-GAS7 induce AML in mice.(A) Survival curves are shown for cohorts (n = 10) of mice injected with MLL-GAS7-transformed cells derived from wild-type (red) and Hoxa7^-/- (blue) bone marrow or mock injected controls (black). (B) Phenotypic analysis of leukemic blasts resulting from MLL-GAS7 transduction of wild-type and Hoxa7^-/- progenitors. Blue profiles represent FACS staining obtained with antibodies specific for the indicated cell surface antigens. Red profiles represent unstained controls or staining obtained with isotype control antibodies. (C) Histologic analysis of tissues from mice injected with MLL-GAS7-transformed wild-type or Hoxa7^-/- cells. Original magnifications for peripheral blood and livers × 1200 and × 40, respectively.