Figure 5.
The effect of the PI3Kδ selective inhibitor on integrin-mediated firm adhesion of neutrophils. (A) Percentage of rolling cells that became stationary for more than 30 seconds upon LTB4 superfusion of CM in vehicle- versus IC87114-treated mice. Results are from 5 experiments for each condition tested. (B) Detachment in flow of resting versus LTB4-activated neutrophils incubated in stasis on CHO cells expressing ICAM-1 at the indicated wall shear stresses in the absence or presence of vehicle control (0.3% DMSO) or IC87114. Mean ± SD for 2 experiments performed in triplicate.
