The impact of IC87114 on endotoxin-induced acute lung injury. (A) Total WBC and neutrophil counts in BAL fluid obtained 6 hours after intratracheal instillation of LPS in the absence or presence of the PI3Kδ inhibitor. Mean number (± SD) of cells contained within BAL fluid as well as plasma levels of inhibitor are shown. Data represent 4 different experiments with 5 or 6 rats in each group. ^*P < .05 versus control. (B) Effect of IC87114 on LPS-induced TNFα release in BAL fluid. Data are mean ± SD of 5 animals in each group, representing 3 separate experiments. (C) Effect of IC87114 on neutrophil viability assessed by relative adenosine triphosphate (ATP) levels. Results represent the mean ± SD for 3 experiments performed in triplicate.